Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.
نویسندگان
چکیده
Single benzamidine group-carrying compounds were shown to interact with the Trypanosoma brucei P2 aminopurine transporter. Replacement of the amidine with a guanidine group decreased affinity. Trypanocidal activity was evident, but compounds were equally toxic against trypanosomes lacking the P2 transporter, which indicates additional uptake routes for monobenzamidine-derived compounds.
منابع مشابه
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 12 شماره
صفحات -
تاریخ انتشار 2005